KOREA HEALTH INDUSTRY DEVELOPMENT INSTITUTE (KHIDI)
发明人:
HAN, Sang-Bae,한상배,KIM, Young Soo,김영수,HONG, Jin Tae,홍진태,Nam, Nguyen-Hai,남응우옌하이,Mai Dung, Do Thi,마이덩두티,Phuong Dung, Phan Thi,푸옹덩판티,Kim Oanh, Dao Thi,킴오안다오티
申请号：
KRKR2013/012036
公开号：
WO2015/016442A1
申请日:
2013.12.23
申请国别(地区):
WO
年份:
2015
代理人:
摘要：
The present invention relates to a novel phenylthiazole-based hydroxamic acid compound and an anti-cancer composition containing same as an active ingredient. A hydroxamic acid compound according to the present invention exhibits anti-cancer effects by having histone deacetylase (HDAC) inhibition activity and cytotoxicity in various cancer cells, and thus can be developed into a powerful active ingredient for an anti-cancer agent.La présente invention porte sur un nouvel acide hydroxamique à base de phénylthiazole et sur une composition anticancéreuse le contenant en tant que principe actif. Un composé acide hydroxamique selon la présente invention présente des effets anticancéreux, du fait quil a une activité dinhibition de lhistone désacétylase (HDAC) et une cytotoxicité vis-à-vis de différentes cellules cancéreuses, de sorte quil peut être développé en un principe actif puissant pour un agent anticancéreux.본 발명은 신규의 페닐티아졸 기반 히드록삼산 화합물 및 이를 유효성분으로 포함하는 항암용 조성물에 관한 것이다. 본 발명의 히드록삼산 화합물은 히스톤 탈아세틸화 효소(histone deacetylase, HDAC)의 억제 활성을 가지며, 다양한 암세포에서 세포독성을 나타내어 항암 효능을 발휘하므로, 강력한 항암제의 활성성분으로 개발될 수 있다.
