ZAMLOOT, MICHAEL,BARBIER, REMI,FRIEDMANN, NADAV,SRIRAMBHATLA, VIJAY,WATT, STEPHEN
申请号：
CA2999509
公开号：
CA2999509A1
申请日:
2016.09.26
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
This invention relates to crystalline salts of naloxone and of naltrexone and their use as opioid antagonists. The crystalline salts of the invention include naloxone saccharinate, naltrexone succinate and a methanol solvate of naltrexone succinate. A drug-in-adhesive transdermal patch containing the opioid analgesic fentanyl or an analog thereof and a crystalline salts of naloxone or naltrexone is disclosed. Also disclosed is a method of treating pain, such as acute, chronic or intermittent pain, by applying a drug-in-adhesive transdermal patch of the invention to the skin of a patient in need thereof.
