Li Gan,Lennart Mucke,Erik Roberson,Sarah Mueller-Steiner
申请号：
US12826403
公开号：
US08388953B2
申请日:
2010.06.29
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tissue. The present invention further provides variant cathepsin B polypeptides that are resistant to inhibition by a cysteine protease inhibitor as well as nucleic acids encoding the variants, and host cells comprising the nucleic acids.
