PROBLEM TO BE SOLVED: To provide compounds that are partial agonists of μ,δ, and κ opioid receptors, and are used for treating pain and opioid addiction, without recidivism; and to provide compositions comprising the same.SOLUTION: This invention relates to a compound represented by formula, where, a bond between Rand Ris a single bond or a double bond; R, R, R, R, R, R, R, R, R, Rand Rare each independently selected from (i) hydrogen, hydroxyl, amino, cyano, and halogen, and (ii) hydrocarbyl and heteroatom-containing hydrocarbyl, each of which (ii) is unsubstituted or substituted; and Ris hydrocarbyl or a carbon-linked heteroatom-containing hydrocarbyl, each of which is unsubstituted or substituted).SELECTED DRAWING: None【課題】μ、δ、及びκオピオイド受容体の部分アゴニストで、疼痛及びオピオイド嗜癖を治療するための常習性のない化合物及び該化合物を含有する組成物の提供。【解決手段】下式で表される化合物。(R7とR8の間の結合は単結合又は二重結合;R1、R2、R3、R4、R5、R6、R6a、R7、R8、R9及びR11は各々独立に(i)水素、ヒドロキシル、アミノ、シアノ、及びハロゲン、並びに(ii)ヒドロカルビル及びヘテロ原子含有ヒドロカルビルから独立して選択され、(ii)の各々は非置換/置換;R10は、ヒドロカルビル又は炭素連結ヘテロ原子含有ヒドロカルビルであり、その各々は非置換/置換)【選択図】なし