Государственное бюджетное образовательное учреждение высшего профессионального образования "Воронежский государственный медицинский университет им. Н.Н. Бурденко" Министерства здравоохранения Российск
发明人:
Великая Ольга Викторовна (RU),Савельев Вячеслав Владимирович (RU)
申请号：
RU2015133317
公开号：
RU2015133317A
申请日:
2015.08.10
申请国别(地区):
RU
年份:
2017
代理人:
摘要：
FIELD: medicine.SUBSTANCE: according to the X-ray computed tomography of chest organs (CO X-ray CT) the largest focus of tuberculous infiltrate - the main focus - is determined. Its mean radius Rmean is calculated: R=(R+R+R)/3, where R, R, Rare the radii of the main focus as a spherical body in three-dimensional space along the x, y, z axes. Then the volume of the main focus is calculated by the formula: V=4/3×πRthe main focus volume change coefficient (M) is calculated: (M)=(VV)×100%, where Vis the volume of the main focus of infiltration on the roentgenogramafter 2 months of treatment, Vis the volume of the main focus of infiltration on the roentgenogram before treatment. If Mexceeds 80%, then the patient has negative dynamics of the tuberculosis process, high risk of multiple drug resistance (MDR) of tuberculosis mycobacteria (TMB), and surgical treatment is recommend. If Mis from 51 to 80%, then the patient has moderate positive dynamics, and chemotherapy is continued for a month with a subsequent evaluation ofM. According to its change of no more than 10% in a month, retained high risk of TMB MDR is judged, and surgical treatment is recommended. If MFVCC is50% or less, the chemotherapy regimen is effective, TMB MDR risk is low and the patient is recommended to continue chemotherapy.EFFECT: method provides individual quantitative prediction of hidden TMB MDR in patients of this group for the subsequent correction of treatment and, accordingly, a decrease in the number of disease relapses.2 ex
