DIELS, GASTON STANISLAS MARCELLA,VERDONCK, MARC GUSTAAF CELINE,BUIJNSTERS, PETER JACOBUS JOHANNES ANTONIUS,VAN EMELEN, KRISTOF
申请号：
CA2687909
公开号：
CA2687909C
申请日:
2008.06.20
申请国别(地区):
CA
年份:
2015
代理人:
摘要：
The present invention relates to compounds or pharmaceutically-acceptable salts thereof, processes for preparing them, pharmaceutical compositions containing them and their use in therapy. The invention particularly relates to certain indolin-2-ones and aza-indolin-2-ones which possess anti-tumour activity and are accordingly useful in methods of treatment of the human or animal body, in particular such compounds are useful in the treatment of pathological processes which involve an aberrant cellular proliferation, such as tumor growth, rheumatoid arthritis, restenosis and atherosclerosis. Formula (I) a N-oxide form, a quaternary anime or a stereochemically isomeric form thereof, wherein Z represents N or CH.
