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METHOD AND APPARATUS FOR PREVENTION OFTHERMO-MECHANICAL FRACTURING IN VITRIFIED TISSUE USING RAPID COOLING ANDWARMING BY PERSUFFLATION
专利权人:
ARIGOS BIOMEDICAL; INC.
发明人:
STEPHEN, VAN SICKLE,史迪芬 范矽可,史迪芬 范矽可,JONES, TANYA,琼斯 塔雅,瓊斯 塔雅
申请号:
TW102123923
公开号:
TW201422155A
申请日:
2013.07.04
申请国别(地区):
TW
年份:
2014
代理人:
摘要:
A method and apparatus are disclosed foravoiding fracturing, e.g., thermo-mechanical fracturing, in vitrifiedbiological systems via rapid cooling and/or warming persufflation techniques,by reducing the domain size of fracturing and by reducing thermalgradients.  Also disclosed is asystem adapted to rapidly cool and warm vitrifiablevascular biological tissue by persufflation, significantly reducingcryoprotectant toxicity from that of surface cooled tissue, in which the systemis constructed and configured to use one or more of helium gas, hydrogen gas,neon gas, argon gas, krypton gas, xenon gas, oxygen gas, or various gaseouscompounds.  The system can beoperated under pressure to increase the density and heat capacity of the gasrelative to its density and heat capacity at atmospheric pressure and to coolthe gas by one or more of mechanical action and by the phase change of amaterial such as a cryogenic gas or solid.本發明提供一種以氣體灌注(persufflation)快速冷卻與升溫,藉由減少破裂區域與熱梯度,預防在玻璃質化生化系統的一種破壞,例如受熱-力而破壞的方法與裝置。本發明亦揭露一種以氣體灌注快速冷卻與升溫玻璃質化生物組織的系統,從表面已冷卻的組織大幅降低低溫防護劑(cryoprotectant)的毒性,其中該系統的構造是用於灌注氦氣、氫氣、氖氣、氬氣、氪氣、氙 氣、氧氣,或以上各種氣體的混合。該系統可操作在加壓下,相對於大氣壓力下操作,可增加氣體的密度與比熱,並利用一或多個機械行動,以及一種低溫防護氣體或固體的相變化,冷卻氣體。1...灌注儲槽2...泵浦3...熱交換器/和氧器4...動脈插管/管柱5...動物/生物組織6...靜脈插管7...返回儲槽8...返回管線
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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