Tsung-Hsun Liu;Allan Gerald Arthur Coombes;Niann-Tzyy Dai;Eric Frank Adams;Ming-Kung Yeh
发明人:
Allan Gerald Arthur Coombes,Eric Frank Adams,Niann-Tzyy Dai,Tsung-Hsun Liu,Ming-Kung Yeh
申请号：
US12447434
公开号：
US08097274B2
申请日:
2006.10.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided herein are skin substitutes suitable for use in a living subject for purpose of repairing damaged tissues, methods of producing the skin substitutes and their uses. A biocomposite membrane comprising poly(ε-caprolactone) (PCL) and at least one material selected from collagen and gelatin is provided. In one embodiment, the biocomposite is a 2-component membrane of PCL and gelatin. In another embodiment, the biocomposite is a 3-component membrane of PCL, collagen and gelatin. The bio-composite membrane may be used directly in vivo as a wound dressing, or as a support for cell growth on each side of the membrane to produce an in vitro cultivated artificial skin for future in vivo and/or in vitro applications.
