PROBLEM TO BE SOLVED: To provide a purified water supply system which is a purified water supply system capable of distributing and supplying purified water produced by purified water production apparatus and in which when disinfecting the purified water supply system, there is no residual chemical solution, the supply of purified water can be restarted in a short time, and the purified water used for disinfection can be reused, and to provide a method for operating the same.SOLUTION: The purified water supply system 1 comprises: a purified water production apparatus 10 for producing purified water a purified water external circulation line 100 for circulating the purified water produced in the purified water production apparatus 10 to the outside of the purified water production apparatus 10 and a purified water distribution line 102 branched from the middle of the purified water external circulation line 100, and in which, in the purified water production apparatus 10, there is provided with a heater (heating means) for heating the purified water.SELECTED DRAWING: Figure 1【課題】精製水製造装置で製造された精製水を分配供給できる精製水供給システムであり、精製水供給システムの消毒を行った際には、薬液の残留がなく、短時間で精製水の供給を再開でき、消毒に用いた精製水を再利用できる精製水供給システムおよびその運転方法を提供する。【解決手段】精製水を製造する精製水製造装置10と;精製水製造装置10で製造された精製水を精製水製造装置10の外部に循環させる精製水外部循環ライン100と;精製水外部循環ライン100の途中から分岐した精製水分配ライン102とを備え;精製水製造装置10には、精製水を加熱するヒータ(加熱手段)が設けられている、精製水供給システム1。【選択図】図1