BOUCHER, Diane M.,HILLIER, Shawn M.,TSAI, Wanjung,HARE, Brian,MARKLAND, William,NEWSOME, David A.,PENNEY, Marina S.
申请号：
EP17857298
公开号：
EP3518931A4
申请日:
2017.09.27
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R1, Q, Ring A, and Ring B are as defined herein.
