Diane M. Boucher,Shawn M. Hillier,Wanjung Tsai,Brian Hare,William Markland,David A. Newsome,Marina S. Penney
申请号：
US16336195
公开号：
US20200016181A1
申请日:
2017.09.27
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Described herein are methods of treating a proliferative disease in a subject by administering a DNA-damaging agent and between about 8 and about 48 hours later administering to the subject a DNA-PK inhibitor. Exemplary DNA-PK inhibitors are represented by Formula (B-I): and by pharmaceutically acceptable salts thereof, wherein R1, Q, Ring A, and Ring B are as defined herein.
