The Rodent Tail Maze is a novel maze to assess anxiety behaviour in mice. The Rodent Tail Maze comprise of a black closed drum shaped chamber of 45 cm height and 30 cm diameter. Maze is connected to a staircase through an opening of 10 cm x 10 cm. The staircase consists of each stair of 20 cm length and 20 cm width and 0.5 cm height. Total number of stairs are 60 in number. The fabrication material of drum may be wooden or any other temperature buffering material that may be helpful to resist change in temperature of the surface of the maze platform. On the other hand, fabrication material of staircase is preferable Plexiglass for clearer visibility of ground from stair(s).