Solid Oral Formulations and Crystalline Forms of an Inhibitor of Apoptosis Protein

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专利权人:

Novartis AG

发明人:

Jeewan THAKUR,Dong YANG,Lili FENG

申请号：

US16120073

公开号：

US20180370960A1

申请日:

2018.08.31

申请国别(地区):

US

年份:

2018

代理人:

摘要：

The present disclosure relates to crystalline form of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, salts and hydrates thereof. This disclosure also relates to solid oral formulation of (S)—N—((S)-1-cyclohexyl-2-{(S)-2-[4-(4-fluoro-benzoyl)-thiazol-2-yl]-pyrrolidin-1-yl}-2-oxo-ethyl)-2-methylamino-propionamide, pharmaceutically acceptable salts, solvates (including hydrates) thereof, as well as methods of treatment using the same.

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