SOLID ORAL FORMULATIONS AND CRYSTALLINE FORMS OF AN INHIBITOR OF APOPTOSIS PROTEIN

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专利权人:

NOVARTIS AG

发明人:

THAKUR,JEEWAN,YANG,DONG,FENG,LILI

申请号：

MYPI 2012000350

公开号：

MY160475A

申请日:

2010.08.11

申请国别(地区):

MY

年份:

2017

代理人:

摘要：

THE PRESENT DISCLOSURE RELATES TO CRYSTALLINE FORM OF (S)-N-((S)-1-CYCLOHEXYL-2-{(S)-2-[4-(4-FLUORO-BENZOYL)-THIAZOL-2-YL]-PYRROLIDIN-1-YL}-2-OXO-ETHYL)-2-METHYLAMINO-PROPIONAMIDE, SALTS AND HYDRATES THEREOF. THIS DISCLOSURE ALSO RELATES TO SOLID ORAL FORMULATION OF (S)-N-((S)-1-CYCLOHEXYL-2-{(S)-2-[4-(4-FLUORO-BENZOYL)-THIAZOL-2-YL]-PYRROLIDIN-1-YL}-2-OXO-ETHYL)-2-METHYLAMINO-PROPIONAMIDE, PHARMACEUTICALLY ACCEPTABLE SALTS, SOLVATES (INCLUDING HYDRATES) THEREOF, AS WELL AS METHODS OF TREATMENT USING THE SAME.

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