The disclosure concerns a pharmaceutical composition in the form of a gastric resident matrix tablet, comprising an active principle, characterized in that when contacted with an environment representing gastric fluid, it increases after 15 minutes in volume, by a swelling of at least 200%.本發明係關於包括一活性成份之呈胃滯留性基質錠片形式之醫藥組合物,其特徵為當與典型胃液介質接觸時其體積增大,經十五分鐘後,溶脹度至少增加200%。