Provided herein are compounds, pharmaceutical compositions, and methods of treatment for various diseases, such as cancer. In one aspect, the method comprises the treatment of brain cancers or metastatic cancers that spread to the brain.本文提供化合物、醫藥組合物,以及各種疾病(諸如癌症)之治療方法。在一個態樣中,該方法包含治療腦癌或擴展至腦的轉移癌。