MOFFAT, DAVID CHARLES FESTUS,PINTAT, STEPHANE,DAVIES, STEPHEN
申请号：
CA2650970
公开号：
CA2650970C
申请日:
2007.05.01
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
Compounds of formula (I) are inhibitors of p38 MAP kinase, and are thereforeof utility in the treatment of, inter alia,inflammatory conditions including rheumatoid arthritis and COPD: (I), wherein:G is -N= or -CH=； D is an optionally substituteddivalent mono- or bi-cyclic aryl or heteroaryl radical having 5 - 13 ringmembers； R6 is hydrogen or optionally substituted C1-C3alkyl； P represents hydrogen and U represents a radical of formula (IA)； or Urepresents hydrogen and P represents a radical offormula -A-(CH2)z-X1-L1-Y-NH-CHRiR2 wherein A represents an optionallysubstituted divalent mono- or bicyclic carbocyclicor heterocyclic radical having 5 - 13 ring members； z, Y, L1, and X1 are asdefined in the specification； R1 is a carboxylic acid group(-COOH), or an ester group which is hydrolysable by one or more intracellularesterase enzymes to a carboxylic acid group； and R2is the side chain of a natural or non-natural alpha amino acid.
