The pharmaceutical composition includes a drug layer comprising an active ingredient, a surfactant, an acidic component and an effervescent ingredient. The active ingredient comprises a nucleic acid, a peptide or a protein. The acidic component and effervescent ingredient of the drug layer are dissolved in the water to react for generating carbon dioxide and bubbles thereof. The surfactants surround the carbon dioxide gas core and form a double-layer structure having an inner layer and outer layer. The active ingredient is embedded in a gap formed between the inner layer and the outer layer of the double-layer structure.本發明提供一種醫藥組成物,用以形成藥物傳遞之多個氣泡。醫藥組成物包括一藥物層,其包含一活性成分、一界面活性劑、一酸性成分以及一起泡劑。活性成分包含核酸、胜肽或蛋白質。藥物層之起泡劑與酸性成分在溶於水後反應產生二氧化碳進而形成氣泡。氣泡以界面活性劑包圍二氧化碳氣體核心並形成一雙層結構,其中雙層結構具有一內層及一外層,活性成分係包埋於雙層結構之內層及外層之間所形成的一間隙中。1‧‧‧奈/微米氣泡11‧‧‧氣體核心12‧‧‧界面活性劑121‧‧‧疏水端122‧‧‧親水端13‧‧‧活性成分
