Nitrogen containing morphinan derivatives and the use thereof

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专利权人:

Purdue Pharma L.P.

发明人:

Jae Hyun Park,Laykea Tafesse

申请号：

US14105724

公开号：

US08937084B2

申请日:

2013.12.13

申请国别(地区):

US

年份:

2015

代理人:

摘要：

The application is directed to compounds of Formula I-Aand pharmaceutically acceptable salts and solvates thereof, wherein R1a-R3a, R4, Y, and Z are defined as set forth in the specification. The invention is also directed to use of compounds of Formula I-A to treat disorders responsive to the modulation of one or more opioid receptors, or as synthetic intermediates. Certain compounds of the present invention are especially useful for treating pain.

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