WEINBERG, CRISTINA-SIMONA,BOVIN, NICOLAI,HENRY, STEPHEN MICHEAL
申请号：
HK10111995.0
公开号：
HK1145708B
申请日:
2010.12.22
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
Peptide-lipid constructs of the structure L-S-F are disclosed, where F is a peptide, S is a spacer covalently linking F to L via an oligomer of ethylene glycol, and L is a diacyl- or dialkyl-glycerolipid (including glycerophospholipids). The spacer ideally has 6 to 14 ethylene glycol repeats, corresponding to PEG with a molecular weight of approximately 250 to 600. Also disclosed is a method of detecting reactive antibodies in serum by contacting serum with cells modified to incorporate a peptide-lipid construct, where the peptide is an epitope of the antibody, and determining the degree of agglutination of the cells.
