A disease management system, methods, and devices are shown and described. In one embodiment, the system includes an infusion pump and a remote controller with the ability to be paired to each other and to confirm the authenticity of instructions sent to the infusion device from the remote controller. A method to verify a wireless connection between an infusion pump and a remote controller is shown and described herein. In addition, a method of operating a diabetes management system is provided in which the system includes an infusion pump and at least a remote controller.