The example systems apparatus and methods use a local perfusion extracorporeal circuit (LPEC) for perfusing a local target region of a body with a systemic perfusion extracorporeal circuit (SPEC) coupled to the core region of the vasculature using a peripheral placed loop to the body and a control procedure to cause the local target region of the body to be at a specified pattern of temperature values that are different than the temperature of the core of the body.