(R) - oxybutynin and (R) - treatment of smooth muscle hyperactivity by desethyloxybutynin

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专利权人:

ファーマシューティカルズ，;ワトソン ファーマシューティカルズ, インコーポレイテッド;インコーポレイテッド;ワトソン

发明人:

アバーグ，エイ・ケイ・ガンナー,アバーグ,エイ・ケイ・ガンナー

申请号：

JP2002501260

公开号：

JP5684964B2

申请日:

2000.06.07

申请国别(地区):

JP

年份:

2015

代理人:

摘要：

The optically pure R(-)-isomer of oxybutynin and the optically pure R(-)-isomer of desethyl-oxybutynin, which are substantially free of the corresponding S(+)-isomers, are potent anticholinergic spasmolytics, useful for relief of symptoms associated with urinary bladder smooth muscle hyperactivity, such as Urinary Incontinence and gastrointestinal smooth muscle hyperactivity, such as Irritable Bowel Syndrome. Methods are disclosed utilizing the optically pure R(-)-isomers of oxybutynin and desethyloxybutynin for treating cholinergically mediated smooth muscle hyperactivity while minimizing the side effects associated with administration of racemic oxybutynin or racemic desethyloxybutynin.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/