NOVEL COMPOUNDS ISOMER THEREOF OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
The present invention relates to novel compounds which act as Vanilloid Receptor 1 (VR1； TRPV1) antagonists, their isomers or their pharmaceutically acceptable salts； And a pharmaceutical composition containing the same. The present invention relates to a pharmaceutical composition for the treatment of pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, Irritable bowel syndrome, fecal urgency, respiratory disorder, skin, eye or mucous membrane, stomach-duodenal ulcer, irritable bowel syndrome, A pharmaceutical composition for preventing or treating diseases such as inflammatory diseases, ear diseases, heart diseases and the like.본 발명은 바닐로이드 수용체(Vanilloid Receptor 1； VR1； TRPV1) 길항제로 작용하는 신규 화합물, 이의 이성질체 또는 이의 약제학적으로 허용 가능한 염； 및 이를 포함하는 약학 조성물에 관한 것이다. 본 발명은 통증, 편두통(migraine), 관절통(arthralgia), 신경통(neuralgia), 신경장해(neuropathies), 신경 손상(nerve injury), 피부 질환(skin disorder), 비뇨 방광 과민증(urinary bladder hypersensitiveness), 과민성대장 증후군(irritable bowel syndrome), 절박배변(fecal urgency), 호흡기 질환(respiratory disorder), 피부, 눈 또는 점막 자극(irritation of skin, eye or mucous membrane), 위-십이지장 궤양(stomach-duodenal ulcer), 염증 질병(inflammatory diseases), 귓병(ear disease), 심장병(heartdisease) 등과 같은 질병의 예방 또는 치료용 약학 조성물을 제공한다.
