Prodrugs of rebamipide Compounds, their Preparation Method, Pharmaceutical composition that comprises； and its use for the Prevention or treatment of gastric ulcer, acute and chronic gastritis, cancer, arthritis, diabetes, irritable bowel syndrome, among other diseases.
CHO EUI-HWAN,CHOI SUNG JU,LEE SUNG WOO,SHIN HEE JONG,KWON HO SEOK,LEE JAE WOONG,JOO JEONG HO,KIM HYUN TAE,SONG WOO-HEON,YOON JONG BAE,PARK KI SEOK,PARK HO JOON,NAM HO TAE
申请号：
CL2014003496
公开号：
CL2014003496A1
申请日:
2014.12.22
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Disclosed are a novel rebamipide prodrug, a method for preparing the same, and use thereof. Also, a pharmaceutical composition comprising the novel rebamipide prodrug as an active ingredient is provided. The rebamipide prodrug is increased 25-fold in absorption rate compared to rebamipide itself, and can be applied to the prophylaxis or therapy of gastric ulcer, acute gastritis, chronic gastritis, xerophthalmia, cancer, osteoarthritis, rheumatoid arthritis, or obesity.COMPUESTOS DERIVADOS DE 2-(4-CLOROBENZOILAMINO)-3-(2-OXO-1,2-DIHIDROQUINOLIN-4-IL)-PROPIONATO； PROCEDIMIENTO DE PREPARACIÓN； COMPOSICIÓN FARMACOLÓGICA； SUS USOS, ÚTILES PARA EL TRATAMIENTO DE ÚLCERA GÁSTRICA, GASTRITIS AGUDA Y CRÓNICA, XEROFTALMIA, CÁNCER, OSTEOARTRITIS, ARTRITIS REUMATOIDE, HIPERLIPIDEMIA, HIPERTRIGLICERIDEMIA, DIABETES, SÍNDROME DE COLON IRRITABLE Y OBESIDAD.
