PROBLEM TO BE SOLVED: To provide solid preparations containing a kneaded and a granulated material which contain a 4-amino-3-butanoic acid (GABA) analog, as well as them both, in which drug stability is maintained, and tableting disorder is suppressed.SOLUTION: A solid preparation is obtained by compounding sugar alcohol or sucrose fatty acid ester into a 4-amino-3-butanoic acid (γ-aminobutyric acid) analog represented by formula (I) to obtain a kneaded material and granulated material having improved stability, and tableting it. The drug stability is maintained, the solid preparation in which tableting disorder is suppressed is obtained, and further calcium stearate is comprised as a lubricant. The compound represented by formula (I) is gabapentin or pregabalin. (R1 is an alkyl R2 is an H or a methyl R1 and R2 are bounded to form a ring R3 is an H, methyl, or carboxyl.)SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】4-アミノ-3-ブタン酸(GABA)類縁体を含有する練合物、造粒物及びこれらを含有する固形製剤で、薬物の安定性が維持され、打錠障害の抑制された固形製剤の提供。【解決手段】式(I)で表される4-アミノ-3-ブタン酸(γ-アミノ酪酸)類縁体に糖アルコール又はショ糖脂肪酸エステルを配合し、安定性の改善された練合物、造粒物を得て、打錠された固形製剤。薬物の安定性が維持され、打錠障害の抑制された固形製剤が得られ、更に、滑沢剤としてステアリン酸カルシウムを含む。式(I)で表される化合物がガバペンチン又はプレババリンである医薬組成物。(R1はアルキル;R2はH又はメチル;R1とR2が結合して環を形成;R3はH、メチル又はカルボキシル)【選択図】なし
