JAMES DAVID JOSEPH,JEFFREY H. HAGER,JING QIAN,JOHN LEE SENSINTAFFAR,NHIN LU,NICHOLAS D. SMITH
申请号：
BR112015001801
公开号：
BR112015001801A2
申请日:
2013.07.26
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
methods and compositions for determining resistance to androgen receptor therapy abstract described herein are modified androgen receptor polypeptides that are resistant to inhibition by an androgen receptor inhibitor. described herein are compositions, combinations, and kits containing the modified androgen receptor polypeptides and methods of using the modified androgen receptor polypeptides. also described herein are methods of using the modified androgen receptor modulators as screening agents for the identification and design of third-generation androgen receptor modulators. also described herein are third-generation androgen receptor modulators that inhibit the activity of the modified androgen receptor polypeptides. also described are pharmaceutical compositions and medications that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions, including cancers, such as castration resistant prostate cancers, that are mediated or dependent upon androgen receptors. "Methods and Compositions for Determining Resistance to Androgen Receptor Therapy" Modified androgen receptor polypeptides which are resistant to inhibition by an androgen receptor inhibitor are described herein. Compositions, combinations and kits which contain the modified androgen receptor polypeptides and methods of using the modified androgen receptor polypeptides are described herein. Also described herein are methods of using modified androgen receptor polypeptides as screening agents for the identification and design of third generation androgen receptor modulators. Also disclosed herein are third generation androgen receptor modulators that inhibit the activity of modified androgen receptor polypeptides. Also described are pharmaceutical compositions and medicaments including the compounds described herein, as well as methods of using such androgen receptor modulators,
