Kevin S. Currie,Zhimin Du,Julie Farand,Juan A. Guerrero,Ashley A. Katana,Darryl Kato,Scott E. Lazerwith,Jiayao Li,John O. Link,Nicholas Mai,Gregory Notte,Hyung-jung Pyun,Michael Sangi,Aaron C. Schmitt
申请号：
US14448160
公开号：
US09376441B2
申请日:
2014.07.31
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein X1, X2, X3, R2, R3, R4, R5, and Y are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.
