Peter A. Blomgren,Kevin S. Currie,Jeffrey E. Kropf,Seung H. Lee,Jennifer R. Lo,Scott A. Mitchell,Aaron C. Schmitt,Sundaramoorthi Swaminathan,Jin-Ming Xiong,Jianjun Xu,Zhongdong Zhao
申请号：
US16413458
公开号：
US20190388419A1
申请日:
2019.05.15
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present disclosure relates to compounds that are Syk inhibitors and to their use in the treatment of various disease states, including cancer and inflammatory conditions. In particular embodiments, the structure of the compounds is given by Formula I:wherein R1, R2, R3, and R4 are as described herein. The present disclosure further provides pharmaceutical compositions that include a compound of Formula I, or pharmaceutically acceptable salts or co-crystals thereof, and methods of using these compounds and compositions to treat conditions mediated by Syk.
