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3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide with selective inhibition of PARP-1
专利权人:
Nerviano Medical Sciences S.r.l.
发明人:
PAPEO, Gianluca Mariano Enrico,ANATOLIEVNA BUSEL, Alina,CASALE, Elena,KHVAT, Alexander,KRASAVIN, Mikhail Yurievitch,ORSINI, Paolo,POSTERI, Helena,SCOLARO, Alessandra
申请号:
ES10728692
公开号:
ES2604305T3
申请日:
2010.07.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I): ** Formula ** characterized in that R is an optionally substituted heterocyclyl or aryl group, the optional substituents being one or more, optionally also linear or branched C1-C6 alkyl groups, C3-C7 cycloalkyl , heterocyclyl, aryl, heteroaryl, C3-C7 cycloalkyl-C1-C6 alkyl heterocyclyl-C1-C6 alkyl, aryl-C1-C6 alkyl or heteroarylalkyl C1-C6 or COR4, and the other optional substituents being one or more halogen groups, alkyl C1-C6, aryl or heterocyclyl, OR7, oxo (>; = O), SR7 or R8O-C1-C6 alkyl group; R1 and R2 are independently hydrogen atom or a linear or branched C1-C6 alkyl group, with the proviso that they are not both hydrogen atoms; R3 is a hydrogen or halogen atom; R4 is OR7; R5 and R6 are independently hydrogen atom or an optionally substituted linear or branched C1-C6 alkyl group, C3-C7 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, heterocyclyl, aryl, heteroaryl, R8R9N-C1-C6 alkyl, R8O -C1-C6 alkyl, or R5 and R6 taken together with the nitrogen atom to which they are attached, form an optionally substituted heterocyclyl group; R7 is a hydrogen atom, a linear or branched C1-C6 alkyl or aryl-C1-C6 alkyl optionally substituted, the substituents being one or more halogen atoms; R8 is a hydrogen atom; R9 is a hydrogen atom or a linear or branched C1-C6 alkyl, C3-C7 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, heterocyclyl, aryl, heteroaryl, COR4 or R8 and R9 is, taken together with the atom of Nitrogen to which they are attached, form an optionally substituted herocyclyl group, where R4 is as defined above, or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula (I):**Fórmula** caracterizado por que R es un grupo heterociclilo o arilo opcionalmente sustituido, siendo los sustituyentes opcionales, uno o varios, opcionalmente también grupos alquilo C1-C6 lineal o ramificado, cicloalquilo C3-C7, heterociclilo, arilo, heteroarilo, cicloalquil C3-C7-alquilo C1-C6 heterociclil-alquilo C1-C6, aril-alquilo C1-C6 o heteroarilalquilo C1
来源网站:
中国工程科技知识中心
来源网址:
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