Crystalline form I of tyrosine kinase inhibitor dimethylate and its preparation processes

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专利权人:

Jiangsu Hengrui Medicine Co.; Ltd.

发明人:

SUN, Piaoyang,WU, Guaili,YUAN, Bo,CHEN, Yongjiang

申请号：

DK13817593

公开号：

DK2873664T3

申请日:

2013.06.04

申请国别(地区):

DK

年份:

2018

代理人:

摘要：

Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl -methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrr olidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmaceutical composition containing the same. Said crystalline Form I of SHR1258 dimaleate has good crystal stability and chemical stability, and can be used in preparation of medicaments for treating diseases relevant to EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase.

来源网站：

中国工程科技知识中心

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http://www.ckcest.cn/home/