The Board of Trustees of the Leland Stanford Junior University
发明人:
Nidhi Bhutani,Jieun Lee,Sarah Taylor
申请号：
US15581950
公开号：
US20170312316A1
申请日:
2017.04.28
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Cell-based therapies for cartilage repair and regeneration selectively using chondrocytes carrying a CD24 surface marker are disclosed. In particular, chondrocytes carrying the CD24 surface marker have a high regenerative potential and low responsiveness to inflammatory cues. Since cartilage injuries as well as chronic cartilage degenerative conditions are often accompanied by a heightened inflammatory environment, cartilage cell populations carrying the CD24 surface marker, which are resistant to the inflammatory environment, provide more efficient cartilage repair. Thus, chondrocytes carrying the CD24 surface marker are useful in cell-based therapies for regenerating or repairing cartilage.
