PROCESS FOR PRODUCING SIMVASTATIN USING NOVEL HYDRAZIDE INTERMEDIATES

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专利权人:

发明人:

PANCHASARA DINESH R,THAPER RAJESH KUMAR,SUSHIL KUMAR DUBEY,KHANNA JAG MOHAN,SANJAY JAISWAL,AKSHAT BHATNAGAR

申请号：

IN108/DEL/2004

公开号：

IN257298B

申请日:

2004.01.21

申请国别(地区):

IN

年份:

2013

代理人:

摘要：

This invention relates to an industrially feasible process for producing HMG-CoA reductase inhibitor, simvastatin via novel intermediates, wherein the process comprises treating lovastatm or lovastatm ammonium salt with hydrazine or hydrazine derivatives to obtain lovastatin hydrazide intermediate, which is further used to produce simvastatin. Further, the hydroxyl groups of said intermediate are optionally protected to obtain protected lovastatin hydrazide intermediate and use the same to produce simvastatin.

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