DE HARO GARCIA, TERESA,DELIGNY, MICHAEL,HEER, JAG PAUL,QUINCEY, JOANNA RACHEL,XUAN, MENGYANG,ZHU, ZHAONING,BROOKINGS, DANIEL CHRISTOPHER,CALMIANO, MARK DANIEL,EVRARD, YVES,HUTCHINGS, MARTIN CLIVE,JOHN
申请号：
CA2962826
公开号：
CA2962826A1
申请日:
2015.10.02
申请国别(地区):
CA
年份:
2016
代理人:
摘要：
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[l,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
