DE HARO GARCIA TERESA,DELIGNY MICHAEL,HEER JAG PAUL,QUINCEY JOANNA RACHEL,XUAN MENGYANG,ZHU ZHAONING,BROOKINGS DANIEL CHRISTOPHER,CALMIANO MARK DANIEL,EVRARD YVES,HUTCHINGS MARTIN CLIVE,JOHNSON JAMES
申请号：
AP201709809
公开号：
AP201709809A0
申请日:
2015.10.02
申请国别(地区):
AP
年份:
2017
代理人:
摘要：
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[1,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
