BROOKINGS, Daniel Christopher,CALMIANO, Mark Daniel,DE HARO GARCIA, Teresa,DELIGNY, Michael,EVRARD, Yves,FILOCHE-ROMME, Bruno,FORICHER, Yann,HEER, Jag Paul,HUTCHINGS, Martin Clive,JADOT, Sophie,JOHNSO
申请号：
TN2017000083
公开号：
TN2017000083A1
申请日:
2015.10.02
申请国别(地区):
TN
年份:
2018
代理人:
摘要：
A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders； neurological and neurodegenerative disorders； pain and nociceptive disorders； cardiovascular disorders； metabolic disorders； ocular disorders； and oncological disorders. In particular, the present invention is concerned with 6,7-dihydro-7,14-methanobenzimidazo[l,2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.
