#$%^&*AU2018203992A120180621.pdf#####LAUR 4512WO ABSTRACT Bolaamphiphilic compounds are provided according to formula I: HG 2 - HG 1 where HG1 , HG2 and L are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering GDNF or NGF into animal or human brain. - 156 -2/41 2.Ox1O0z1.5xlo-7-H< .OxlO o 1 2 3 4 5 6 7 8 9 10 11 Time (min) FIG. 2A