DVORAK, Curt A.,FITZGERALD, Anne E.,SHIREMAN, Brock T.,LEBOLD, Terry P.,COATE, Heather R.,PREVILLE, Cathy
申请号：
MX2015011816
公开号：
MX2015011816A
申请日:
2014.03.12
申请国别(地区):
MX
年份:
2016
代理人:
摘要：
The present invention is directed to compounds of Formula I: wherein ring A is phenyl, naphihalenyl, pyridyl, quinolinyl, isoquinolinyl, imidazopyridyl, furanyi, tlisazolyl, isoxazolvl, pyrazolyl, imidazothiazolyi, benzimidazolyl, or indazolyi； R1 is H, alky], aikoxy, hydroxyalkylene, OH, halo, phenyl, triazolyl, oxazolyl, isoxazofyl, pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, piperazinyl, pyrazolyl, oxadiazolvl, pyrrolidinyl, thiophenyi, morpholinyl, or dialkyiamino； R2 is H, alkyl, aikoxy, hydroxyalkylene, or halo； Z is NH, N- alkyl, or O； R5 is pyridyl, pyrimidinyl, pyrazinyl, pyridazmyl, qumazolinyi, quinoxalinyl, pyrazolyl, benzoxazolyl, imidazopyrazinyl, triazolopyrazinyl, optionally substituted with a one or two substiiuents independently selected from the group consisting of alkyl, aikoxy, or halo； and n is 0 or 1, Methods of making the compounds of Formula 1 are also described. The invention also relates to pharmaceutical compositions comprising compounds of Formula I. Methods of using the compounds of the invention are also within the scope of the invention.La presente invención está dirigida a compuestos de la Fórmula I: (ver Fórmula) en donde el anillo A es fenilo, nafihalenilo, piridilo, quinolinilo, isoquinolinilo, imidazopiridilo, furanilo, tlisazolilo, isoxazolilo, pirazolilo, imidazotiazolilo, bencimidazolilo o indazolilo； R1 es H, alquilo, alcoxi, hidroxialquileno, OH, halo, fenilo, triazolilo, oxazolilo, isoxazofilo, piridilo, pirimidinilo, pirazinilo, piridazmilo, piperazinilo, pirazolilo, oxadiazolilo, pirrolidinilo, tiofenilo, morfolinilo o dialquilamino； R2 es H, alquilo, alcoxi, hidroxialquileno o halo； Z es NH, N-alquilo u O； R5 es piridilo, pirimidinilo, pirazinilo, piridazmilo, cumazolinilo, quinoxalinilo, pirazolilo, benzoxazolilo, imidazopirazinilo, triazolopirazinilo, sustituidos opcionalmente con uno o dos sustituyentes seleccionados independientemente del grupo que consiste en alquilo, alcoxi o halo； y n es 0 ó 1； también se descr
