ПЕТЕРС Дан (DK),ТИММЕРМАНН Даниель Б. (DK),НИЕЛЬСЕН Эльсебет Эстергорд (DK),КРИСТОФФЕРСЕН Эва Дам (DK)
申请号：
RU2010135037/15
公开号：
RU2010135037A
申请日:
2009.03.09
申请国别(地区):
RU
年份:
2012
代理人:
摘要：
1. The N-oxide derivative of 1,4-diazabicyclo [3.2.2] nonyloxyadiazolyl of the formula I! ! or its pharmaceutically acceptable salt, where! Ar is a phenyl group substituted with a methylenedioxy or ethylenedioxy group. ! 2. The N-oxide of the 1,4-diazabicyclo [3.2.2] nonyloxyadiazolyl derivative according to claim 1 or a pharmaceutically acceptable salt thereof, wherein Ar is a phenyl group substituted with a methylenedioxy group. ! 3. The N-oxide of the 1,4-diazabicyclo [3.2.2] nonyloxyadiazolyl derivative according to claim 1, or a pharmaceutically acceptable salt thereof, wherein Ar is a phenyl group substituted with an ethylenedioxy group. ! 4. The N-oxide derivative of 1,4-diazabicyclo [3.2.2] nonyloxadiazolyl according to claim 1, which is 4- (5-benzo [1,3] dioxol-5-yl- [1,3,4] oxadiazole- 2-yl) -1,4-diazabicyclo [3.2.2] nonan-1-oxide； ! or a pharmaceutically acceptable salt thereof. ! 5. A pharmaceutical composition comprising a therapeutically effective amount of N-oxide of a 1,4-diazabicyclo [3.2.2] nonyloxyadiazolyl derivative according to any one of claims 1 to 4, or a pharmaceutically acceptable addition salt thereof, together with at least one pharmaceutically acceptable carrier or diluent. ! 6. The use of the N-oxide derivative of 1,4-diazabicyclo [3.2.2] nonyloxadiazolyl according to any one of claims 1 to 4 or a pharmaceutically acceptable addition salt thereof for the manufacture of a pharmaceutical composition / medicament for treating, preventing or alleviating a disease, or disorder, or a mammalian condition, including humans, where the disease, disorder or condition is sensitive to modulation of cholinergic receptors. ! 7. The use of claim 6, wherein the disease, disorder or condition is a cognitive1. N-оксид производного 1,4-диазабицикло[3.2.2]нонилоксадиазолила формулы I ! ! или его фармацевтически приемлемая соль, где ! Аr представляет собой фенильную группу, замещенную метилендиокси- или этилендиокси-группой. ! 2. N-оксид производного
