MOLÉCULE SE LIANT À L'ANTIGÈNE POUR FAVORISER LA CLAIRANCE DU PLASMA D'UN ANTIGÈNE COMPRENANT UN DOMAINE DE LIAISON AUX RÉCEPTEURS DE TYPE CHAÎNE SACCHARIDIQUE

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专利权人:

Chugai Seiyaku Kabushiki Kaisha

发明人:

申请号：

EP12838341.1

公开号：

EP2765192A1

申请日:

2012.10.05

申请国别(地区):

EP

年份:

2014

代理人:

摘要：

Disclosed are an antigen-binding molecule containing a sugar chain receptor-binding domain and having a weak antigen-binding activity in the pH of early-stage endosome compared to the antigen-binding activity in the pH of plasma； a pharmaceutical composition containing the antigen-binding molecule； and a method for producing these. Use of the antigen-binding molecule of the invention enables to promote uptake of an antigen into a cell and increase the number of antigens that a single antibody molecule can bind. Administration of the antibody enables to reduce the number of antigens in plasma more and more and improve pharmacokinetics of the antibody.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/