James E. Hansen;Robert N. Nishimura;Grace Chan;Peter M. Glazer;Richard H. Weisbart
发明人:
James E. Hansen,Peter M. Glazer,Richard H. Weisbart,Robert N. Nishimura,Grace Chan
申请号：
US14009327
公开号：
US09701740B2
申请日:
2012.04.02
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
