Disclosed herein are phage-displayed single-chain variable fragment (scFv) libraries, which comprised a plurality of scFvs with a specific sequence in each CDR. The present scFv libraries could be used to efficiently produce different antibodies with high binding affinity to H1 hemagglutinin of influenza virus. Accordingly, the present disclosure provides a potential means to generate different antigen-specific antibodies promptly in accordance with the need in experimental researches and/or clinical applications.本揭示內容是關於由噬菌體呈現之單鏈變異片段抗體庫,其係包含複數個單鏈變異片段,其中各單鏈變異片段之各CDR分別具有特定胺基酸序列。利用本發明單鏈變異片段抗體庫可有效製備對流感病毒之H1血球凝集素具有高度結合親和力的各式不同抗體。據此,本揭示內容可依據實驗研究及/或臨床應用的需求,即時製備對抗原具有專一性的不同抗體。
