Dennis Kaetzel,Matthew Charles Walker,Stephanie Schorge,Dimitri Michael Kullmann
申请号：
US15125762
公开号：
US20160375097A1
申请日:
2015.03.06
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides methods and materials for treating a seizure disorder such as epilepsy in a patient which employ a vector encoding a modified receptor, the so-called “DREADD” receptor being characterised by (i) a decreased responsiveness to its endogenous activating ligand (ii) a retained or enhanced responsiveness to an exogenous agonist. The modified receptor is expressed in neurons of a seizure focus in brain of the patient, and an exogenous agonist is administered which activates the modified receptor to reversibly alters the excitability of the neurons in the seizure focus leading to synaptic silencing or other inhibition.
