An apparatus for anticipating and facilitating metabolic activity of an occupant in a vehicle includes a measurement part measuring a volume of a bladder using a sensor mounted in the vehicle a rest area information calculator calculating information on a rest area including a distance to the rest area which may be reached within a predetermined time or an expected time of arrival to the rest area which may be reached, according to rest area location information and vehicle speed information and a guidance part providing indication information including the volume of the bladder or the information on the rest area.