The present invention relates to use of Jatropha curcas latex (J. latex) as a natural inhibitor in development of stable nanosuspension prepared by wet milling technique using 32 factorial design. Inhibitory effect of J. curcas was studied in comparison with hydroxy propyl methylcellulose (HPMC) and sodium lauryl sulphate (SLS). The ability of J. curcas to stabilize the nanosuspension was predicated by studying molecular interaction between the felodipine and latex using molecular docking. Results shows, initial crystalline state of drug is preserved followed by particle size reduction, with increase in saturation solubility, dissolution velocity and diffusion rate of the drug from the nanosuspension than that of the plain drug suspension and marketed formulation. Noteworthy, J. curcas latex serves as natural inhibitor to prepare many formulations with minimized toxicity, as it is biodegradable and has low toxicity then synthetic inhibitors.
