KUO, TSUN YUNG,郭村勇,CHEN, HSU CHUNG GABRIEL,陈旭中,陳旭中,YANG, SHU HSIANG,杨舒翔,楊舒翔,CHEN, YU SAN,陈裕森,陳裕森
申请号：
TW101144533
公开号：
TW201323437A
申请日:
2012.11.28
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The invention relates to a procine circovirus type 2 (PCV2) immunogenic composition having an antigenic peptide. The antigenic peptide is a non-arginine-rich peptide of PCV2 open reading frame 2 (ORF2) and/ or a recombinant fusion protein that is a construction of the non-arginine-rich peptide of PCV2 ORF2, a PE peptide, and a KDEL signal peptide. The arginine numbers of the non-arginine-rich peptide of PCV2 ORF2 are not more than half of the arginine numbers of the arginine-rich domain of the N terminal of PCV2 ORF2.本發明係關於一種抗豬第二型環狀病毒(PCV2)免疫組合物，包含一抗原胜肽，該抗原胜肽係為PCV2第二開放閱讀區(open reading frame 2,ORF2)非富含精胺酸胜肽(non-Arginine-rich peptide)及/或將該PCV2 ORF2非富含精胺酸胜肽進一步與一PE胜肽及一KDEL胜肽構築形成之一重組融合蛋白。該PCV2 ORF2非富含精胺酸胜肽之精胺酸數量係為PCV2 ORF2全長胜肽之N端富含精胺酸區域(Arginine-rich domian)之精胺酸數量的二分之一以下。
