HARTMAN, Jacob, R., 58363 Holon, IL,MENDELOVITZ, Simona, 69341 Tel Aviv, IL,GORECKI, Marian, 76300 Rehovot, IL
申请号：
DE69434909
公开号：
DE000069434909T3
申请日:
1994.12.29
申请国别(地区):
DE
年份:
2012
代理人:
摘要：
A new method for the prodn. of recombinant human insulin comprises: folding a hybrid polypeptide comprising proinsulin under conditions that permit correct disulphide bond formation； subjecting folded protein to enzymatic cleavage and purifying produced. Also new is polypeptide that contains a leader peptide attached to the N terminus of, is folded and contains correct disulphide bonds.
