GOVERNMENT OF THE UNITED STATES OF AMERICA; REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
TARASOVA, NADYA,DEAN, MICHAEL,LOU, HONG
申请号：
MYPI 20091748
公开号：
MY149170A
申请日:
2007.10.30
申请国别(地区):
MY
年份:
2013
代理人:
摘要：
DISCLOSED IS AN ISOLATED OR PURIFIED POLYPEPTIDE OR PEPTIDOMIMETIC COMPRISING AN AMINO ACID SEQUENCE OF A PORTION OF A SMOOTHENED (SMO) PROTEIN, WHEREIN THE PORTION COMPRISES AN AMINO ACID SEQUENCE OF ANY OF THE INTRACELLULAR LOOPS OF THE SMO PROTEIN, A FUNCTIONAL FRAGMENT THEREOF, OR A FUNCTIONAL VARIANT OF EITHER THE PORTION OR THE FUNCTIONAL FRAGMENT, WHEREIN THE FUNCTIONAL FRAGMENT COMPRISES AT LEAST 7 CONTIGUOUS AMINO ACIDS OF THE INTRACELLULAR LOOPS, AND WHEREIN THE FUNCTIONAL FRAGMENT OR FUNCTIONAL VARIANT INHIBITS PROLIFERATION OF A DISEASED CELL, OR A FATTY ACID DERIVATIVE THEREOF. RELATED CONJUGATES, NUCLEIC ACIDS, RECOMBINANT EXPRESSION VECTORS, HOST CELLS, AND PHARMACEUTICAL COMPOSITIONS ARE FURTHER PROVIDED. METHODS OF INHIBITING PROLIFERATION OF A DISEASED CELL, TREATING OR PREVENTING CANCER, TREATING A NEOPLASM OR PSORIASIS, AND INHIBITING THE EXPRESSION OF GENES INVOLVED IN THE HEDGEHOG SIGNALING PATHWAY, THEREBY INHIBITING THE HEDGEHOG SIGNALING PATHWAY, ARE FURTHERMORE PROVIDED BY THE INVENTION.
