Curie Ahn,Byeong Chun Lee,Jong Ik Hwang,Jae Seok Yang,Byoung Gon Moon,Goo Jang,Bum Rae Cho,Ok Jae Koo,Sol Ji Park,Jung Taek Kang,Dae Kee Kwon
申请号：
US13980846
公开号：
US09357754B2
申请日:
2012.01.20
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced a method for preparing the same an organ isolated from the transgenic pig a somatic donor cell line inserted with sTNFR1-Fc gene a method for preparing a blood sample comprising sTNFR1-Fc and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-α in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.
