UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
TAI, CHANGFENG
申请号：
CA3006451
公开号：
CA3006451A1
申请日:
2016.12.01
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Provided herein are methods of nerve blockage, for example for treatment of obesity, heart failure, cardiovascular disease, muscle spasms, chronic pain, or urinary retention in a patient. The method comprises first heating a nerve above physiological temperature (e.g. 37°C in a human), such as from 43°C to 54°C for a duration that leads to reversible nerve blockage as opposed to nerve damage. Second, reversible nerve blockage is produced by cooling the nerve below physiological temperature to a temperature in which reversible nerve blockage is achieved, for example from 15°C to 30°C.
